Biotin and derivatives
Apexbio Technology LLC Sulfo-NHS-Biotin Kit (90-180 kDa) 3samples
Sulfo-NHS-Biotin labeling is widely utilized in biochemical research to covalently conjugate biotin molecules to free amino groups on protein molecules primarily lysine residues and N-terminal amines The reaction proceeds via activated ester intermediates forming stable amide bonds that facilitate subsequent detection or purification using streptavidin-biotin affinity interactions This labeling method is routinely applied to diverse protein samples particularly immunoglobulin G and other antibodies (molecular weight 90-180 kDa) enabling downstream applications such as immunoassays Western blotting immunoprecipitation and flow cytometry analyses Commonly the labeled proteins are purified rapidly by spin-based filtration to eliminate unreacted small molecules improving purity and yield
Medchemexpress LLC DBCO-NHS ester | 1353016-71-3 | 99.1% | 402.40 g·mol⁻1 | C23H18N2O5 | 5 MG
DBCO-NHS ester is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester for copper-free click bioconjugation via strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to install linkers and conjugate azide-bearing molecules in chemical biology and antibody-drug conjugate (ADC) workflows.
- Enables copper-free SPAAC with azide-containing molecules.
- Suitable for linker installation and bioconjugation in ADC and biomolecule conjugation workflows.
- Reported high purity for analytical and preparative use.
- Available in small research quantities, including 5 MG format.
Medchemexpress LLC DBCO-NHS ester 3 50mg | 1393350-27-0 | 416.43 g/mol | C24H20N2O5 | 50 MG
DBCO-NHS ester 3 is an amine-reactive dibenzylcyclooctyne (DBCO) N-hydroxysuccinimide (NHS) ester used for copper-free click chemistry and as a linker in antibody-drug conjugate and bioconjugation workflows. It reacts with primary amines to install a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners.
- Amine-reactive NHS ester for efficient conjugation to primary amines.
- Facilitates copper-free strain-promoted alkyne-azide cycloaddition (SPAAC).
- Suitable for use as a linker in antibody-drug conjugate and bioconjugation workflows.
- Supplied as a white to off-white solid, compatible with low-temperature storage.
- Typical purity around 95.6% and molecular weight 416.43 g/mol support reliable reaction performance.
Medchemexpress LLC DBCO-PEG12-NHS ester | 2093934-94-0 | 96.1% | C50H71N3O18 | 25 MG
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Features a DBCO group for SPAAC
- Facilitates strain-promoted alkyne-azide cycloaddition with azide groups
- PROTACs utilize the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG12-NHS ester | 1934296-88-4 | 99.3% | C41H72N4O18S | 100 MG
Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. This compound utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
- For research use only
Medchemexpress LLC CA125 Human Biotin 20ug | 20ug
The CA125 protein acts by binding to MSLN and plays a crucial role in forming a protective and lubricating barrier on mucosal surfaces This interaction promotes heterotypic cell adhesion and is suggested to play an important role in peritoneal metastasis of ovarian cancer CA125 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived CA125 protein expressed by HEK293 with C-Avi C-His labeled tag
![eMolecules 2252392-53-1 | Azido-PEG11-alcohol | Broadpharm | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203274.JPG-250.jpg)
eMolecules 2252392-53-1 | Azido-PEG11-alcohol | Broadpharm | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197
Azido-PEG11-alcohol | Broadpharm | 2252392-53-1 | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197
Medchemexpress LLC Biotin-PEG2-NHS ester | 596820-83-6 | 96.7% | C21H32N4O8S | 50 MG
Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- For research use only
- White to off-white solid appearance
- Molecular weight of 500.57
- Powder can be stored at -20°C for 3 years
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 125 mg/mL
Medchemexpress LLC B7-H6 Human Biotin 50ug | 50ug
B7-H6 a distinctive monomeric protein uniquely triggers NCR3-dependent natural killer (NK) cell activation specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1 NCR2 and KLRK1) This specificity underscores B7-H6 s unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms B7-H6 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H6 protein expressed by HEK293 with C-His C-Avi labeled tag
eMolecules 756525-90-3 | M-PEG8-NHS ESTER | AstaTech | MFCD13184969 | 509.549 | C22H39NO12 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 624137097
M-PEG8-NHS ESTER | AstaTech | 756525-90-3 | MFCD13184969 | 509.549 | C22H39NO12 | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 1g | 624137097
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 50 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC PCSK9 Human Biotin 5ug | 5ug
The PCSK9 protein is an important regulator of plasma cholesterol homeostasis affecting LDL receptor family members such as LDLR and VLDLR It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms PCSK9 Protein Human (Biotinylated HEK293 D374Y His-Avi) is the recombinant human-derived PCSK9 protein expressed by HEK293 with C-Avi C-His labeled tag and D374Y mutation
Sigma Aldrich Fine Chemicals Biosciences Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 10MG
Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 10MG
Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-propanoate | 2395839-96-8 | MFCD11041155 | 99.9% | C54H103NO28 | 10MG
m-PEG24-NHS ester is a methyl-capped polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) activated ester. It is designed for coupling to primary amines and is commonly used as a hydrophilic spacer in the synthesis of PROTACs, bioconjugates, and other bifunctional molecules where controlled spacing and solubility are required.
- Methyl-capped PEG24 spacer with terminal NHS ester for efficient amine coupling.
- High purity suitable for synthetic and bioconjugation workflows.
- Hydrophilic and flexible linker improves solubility and reduces steric hindrance.
- Compatible with standard NHS-ester coupling conditions.
- Available in laboratory-scale quantities for research and development use.
Medchemexpress LLC Sulfo-NHS-Biotin sodium | 194041-65-1 | 95.0% | 443.43 | 1 ML
Sulfo-NHS-Biotin sodium is a low-molecular-weight (443.4 Da) tracer designed to assess blood-brain barrier permeability. It is intended for research use only.
- Low molecular weight tracer
- Assesses blood-brain barrier permeability
- Utilized in traumatic brain injury models